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Inflammatory chemokines and metastasis - tracing the accessory.
Oncogene 33, 3217-3224 (2013)
The tumor microenvironment consists of stromal cells and leukocytes that contribute to cancer progression. Cross-talk between tumor cells and their microenvironment is facilitated by a variety of soluble factors, including growth factors and cytokines such as chemokines. Due to a wide expression of chemokine receptors on cells in the tumor microenvironment, including tumor cells, chemokines affect various processes such as leukocyte recruitment, angiogenesis, tumor cell survival, tumor cell adhesion, proliferation, vascular permeability, immune suppression, invasion and metastasis. Inflammatory chemokines are instrumental players in cancer-related inflammation and significantly contribute to numerous steps during metastasis. Recruitment of myeloid-derived cells to metastatic sites is mainly mediated by the inflammatory chemokines CCL2 and CCL5. Tumor cell homing and extravasation from the circulation to distant organs are also regulated by inflammatory chemokines. Recent experimental evidence demonstrated that besides leukocyte recruitment, tumor cell-derived CCL2 directly activated endothelial cells and together with monocytes facilitated tumor cell extravasation, in a CCL2- and CCL5-dependent manner. Furthermore, CX3CL1 expression in the bone facilitated metastasis of CX3CR1 expressing tumor cells to this site. Current findings in preclinical models strongly suggest that inflammatory chemokines have an important role during metastasis and targeting of the chemokine axis might have a therapeutic potential.
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Publication type Article: Journal article
Document type Review
Keywords Tumor cell extravasation; Inflammatory chemokines; CCL2; CCL5; Metastasis; Breast-cancer Cells; Monocyte Chemoattractant Protein-1; Tumor-growth; Endothelial-cells; Lung Metastasis; Suppressor-cells; Up-regulation; B16 Melanoma; Stem-cells; In-vivo
ISSN (print) / ISBN 0950-9232
Quellenangaben Volume: 33, Issue: 25, Pages: 3217-3224
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)