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Gewies, A. ; Castineiras-Vilarino, M.* ; Ferch, U.* ; Jährling, N.* ; Heinrich, K.* ; Hoeckendorf, U.* ; Przemeck, G.K.H. ; Munding, M. ; Groß, O.* ; Schroeder, T. ; Horsch, M. ; Karran, E.L.* ; Majid, A.* ; Antonowicz, S.* ; Beckers, J. ; Hrabě de Angelis, M. ; Dodt, H.U.* ; Peschel, C.* ; Förster, I.* ; Dyer, M.J.S.* ; Ruland, J,

Prdm6 is essential for cardiovascular development in vivo.

PLoS ONE 8:e81833 (2013)
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Open Access Gold
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Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Transcriptional Repressor Blimp-1 ; T-cell Homeostasis ; Vascular Development ; Smooth-muscle ; Endothelial-cells ; Breast-cancer ; Mice Lacking ; Yolk-sac ; Angiogenesis ; Gene
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 8, Issue: 11, Pages: , Article Number: e81833 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed