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Prdm6 is essential for cardiovascular development in vivo.

PLoS ONE 8:e81833 (2013)
Publishers Version DOI PMC
Open Access Gold
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Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Transcriptional Repressor Blimp-1 ; T-cell Homeostasis ; Vascular Development ; Smooth-muscle ; Endothelial-cells ; Breast-cancer ; Mice Lacking ; Yolk-sac ; Angiogenesis ; Gene
Reviewing status