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Vinceti, M.* ; Mandrioli, J.* ; Borella, P.* ; Michalke, B. ; Tsatsakis, A.* ; Finkelstein, Y.*

Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies.

Toxicol. Lett. 230, 295-303 (2014)
Verlagsversion Postprint Manuscript DOI
Open Access Green
Selenium is a metalloid of considerable interest in the human from both a toxicological and a nutritional perspective, with a very narrow safe range of intake. Acute selenium intoxication is followed by adverse effects on the nervous system with special clinical relevance, while the neurotoxicity of long-term overexposure is less characterized and recognized. We aimed to address this issue from a public health perspective, focusing on both laboratory studies and the few epidemiologic human studies available, with emphasis on their methodological strengths and limitations. The frequently overlooked differences in toxicity and biological activity of selenium compounds are also outlined. In addition to lethargy, dizziness, motor weakness and paresthesias, an excess risk of amyotrophic lateral sclerosis is the effect on the nervous system which has been more consistently associated with chronic low-level selenium overexposure, particularly to its inorganic compounds. Additional research efforts are needed to better elucidate the neurotoxic effects exerted by selenium overexposure.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Selenium ; Neurotoxicity Syndromes ; Nervous System Diseases ; Amyotrophic Lateral Sclerosis ; Epidemiologic Studies ; Risk Assessment; Amyotrophic-lateral-sclerosis; Motor-neuron Disease; Prostaglandin-d Synthase; Long-term Exposure; Sodium Selenite; Dietary Selenium; Inorganic Selenium; Selenoprotein P; Drinking-water; Environmental Selenium
ISSN (print) / ISBN 0378-4274
e-ISSN 1879-3169
Zeitschrift Toxicology Letters
Quellenangaben Band: 230, Heft: 2, Seiten: 295-303 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed