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Dahlhoff, M.* ; Pfister, S.* ; Blutke, A.* ; Rozman, J. ; Klingenspor, M.* ; Deutsch, M.J.* ; Rathkolb, B. ; Fink, B.* ; Gimpfl, M.* ; Hrabě de Angelis, M. ; Roscher, A.A.* ; Wolf, E.* ; Ensenauer, R.*

Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.

Biochim. Biophys. Acta-Mol. Basis Dis. 1842, 304–317 (2014)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Vulnerability of the fetus upon maternal obesity can potentially occur during all developmental phases. We aimed at elaborating longer-term health outcomes of fetal overnutrition during the earliest stages of development. We utilized NMRI mice to induce pre-conceptional and gestational obesity and followed offspring outcomes in the absence of any postnatal obesogenic influences. Male adult offspring developed overweight, insulin resistance, hyperleptinemia, hyperuricemia and hepatic steatosis; all these features not being observed in females. Instead, those showed impaired fasting glucose and a reduced fat mass and adipocyte size. Influences of the interaction of maternal diet*sex concerned offspring genes involved in fatty liver disease, lipid droplet size regulation and fat mass expansion. These data suggest that a peri-conceptional obesogenic exposure is sufficient to shape offspring gene expression patterns and health outcomes in a sex- and organ-specific manner, indicating varying developmental vulnerabilities between sexes towards metabolic disease in response to maternal overnutrition.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Obesity ; Peri-conceptional ; Pregnancy ; Offspring ; Programming ; Sex-specificity; High-fat Diet; Maternal Obesity; Adipose-tissue; Insulin-resistance; Leptin Resistance; Gene-expression; Adipocyte Size; Liver-disease; Mice; Pregnancy
ISSN (print) / ISBN 0925-4439
e-ISSN 1878-2434
Quellenangaben Band: 1842, Heft: 2, Seiten: 304–317 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed