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Brüske, I. ; Thiering, E. ; Heinrich, J. ; Huster, K.M.* ; Nowak, D.*

Biopersistent granular dust and chronic obstructive pulmonary disease: A systematic review and meta-analysis.

PLoS ONE 8:e80977 (2013)
Verlagsversion Volltext DOI
Open Access Gold
Creative Commons Lizenzvertrag
OBJECTIVE: Applying a systematic review to identify studies eligible for meta-analysis of the association between occupational exposure to inorganic dust and the development of chronic obstructive pulmonary disease (COPD), and conducting a meta-analysis. DATA SOURCES: Searches of PubMed and Embase for the time period 1970-2010 yielded 257 cross-sectional and longitudinal studies on people exposed to inorganic dust at the workplace with data on lung function. These studies were independently abstracted and evaluated by two authors; any disagreement was resolved by a third reviewer. Of 55 publications accepted for meta-analysis, 27 investigated the effects of occupational exposure to biopersistent granular dust (bg-dust). METHODS: A random effects meta-analysis allowed us to provide an estimate of the average exposure effect on spirometric parameters presented in forest plots. Between-study heterogeneity was assessed by using I(2) statistics, with I(2)>25% indicating significant heterogeneity. Publication bias was investigated by visual inspection of funnel plots. The influence of individual studies was assessed by dropping the respective study before pooling study-specific estimates. RESULTS: The mean FEV1 of workers exposed to bg-dust was 160 ml lower or 5.7% less than predicted compared to workers with no/low exposure. The risk of an obstructive airway disease-defined as FEV1/FVC < 70%-increased by 7% per 1 mg· m(-3) respirable bg-dust. CONCLUSION: Occupational inhalative exposure to bg-dust was associated with a statistically significant decreased FEV1 and FEV1/FVC revealing airway obstruction consistent with COPD.  
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Nutrition-examination-survey ; Air-flow Limitation ; African Gold Miners ; Lung-function ; Respiratory Symptoms ; Occupational-exposure ; Ventilatory Function ; General-population ; Norwegian Smelters ; Rubber Workers
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 8, Heft: 11, Seiten: , Artikelnummer: e80977 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed