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Casas, L.* ; Tischer, C.G. ; Wouters, I.M.* ; Torrent, M.* ; Gehring, U.* ; García-Esteban, R.* ; Thiering, E. ; Postma, D.S.* ; de Jongste, J.* ; Smit, H.A.* ; Borras-Santos, A.* ; Zock, J.P.* ; Hyvärinen, A.* ; Heinrich, J. ; Sunyer, J.*

Early life microbial exposure and fractional exhaled nitric oxide in school-age children: A prospective birth cohort study.

Environ. Health 12:103 (2013)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Inflammation is a key factor in the pathogenesis of respiratory diseases. Early life exposure to microbial agents may have an effect on the development of the immune system and on respiratory health later in life.In the present work we aimed to evaluate the associations between early life microbial exposures, and fractional exhaled nitric oxide (FeNO) at school age. METHODS: Endotoxin, extracellular polysaccharides (EPS) and beta(1,3)-D-glucan were measured in living room dust collected at 2--3 months of age in homes of participants of three prospective European birth cohorts (LISA, n = 182; PIAMA, n = 244; and INMA, n = 355). Home dampness and pet ownership were periodically reported by the parents through questionnaires. FeNO was measured at age 8 for PIAMA and at age 10/11 for LISA and INMA. Cohort-specific associations between the indoor microbial exposures and FeNO were evaluated using multivariable regression analyses. Estimates were combined using random-effects meta-analyses. RESULTS: FeNO at school age was lower in children exposed to endotoxin at age 2--3 months (beta -0.05, 95% confidence interval (CI) -0.10;-0.01) and in children with reported dog ownership during the first two years of life (GM ratio 0.82, CI 0.70-0.96). FeNO was not significantly associated with early life exposure to EPS, beta(1,3)-D-glucan, indoor dampness and cat ownership. CONCLUSION: Early life exposure to bacterial endotoxin and early life dog ownership are associated with lower FeNO at school age. Further studies are needed to confirm our results and to unravel the underlying mechanisms and possible clinical relevance of this finding.  
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Fractional Exhaled Nitric Oxide ; Endotoxin ; Extracellular Polysaccharides ; Beta(1,3)-d-glucan ; Pets ; Dampness ; Indoor ; Children ; Cohort Study; House-dust Endotoxin; Allergen-induced Sensitization; High-risk; Airway Inflammation; Childhood Asthma; Dog Ownership; Mold Components; Mite Allergen; Atopy; Symptoms
e-ISSN 1476-069x
Quellenangaben Band: 12, Heft: 1, Seiten: , Artikelnummer: 103 Supplement: ,
Verlag BioMed Central