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Wagner, R.* ; Heni, M.* ; Linder, K.* ; Ketterer, C.* ; Peter, A.* ; Böhm, A.* ; Hatziagelaki, E.* ; Stefan, N. ; Staiger, H. ; Häring, H.-U. ; Fritsche, A.

Age-dependent association of serum prolactin with glycaemia and insulin sensitivity in humans.

Acta Diabetol. 51, 71-78 (2014)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The dopamine agonist bromocriptine has been approved for the treatment of type 2 diabetes in the United States. Bromocriptine inhibits prolactin secretion, and patients with hyperprolactinaemia display impaired insulin sensitivity. We therefore hypothesized that low prolactin levels are associated with lower glycaemia and higher insulin sensitivity in healthy subjects. Prolactin levels were determined from fasting serum in participants without diabetes from the cross-sectional Tübingen family study for type 2 diabetes (m/f = 562/1,121, age = 40 ± 13 years, BMI = 30 ± 9 kg/m(2)). A 75 g oral glucose tolerance test was performed, and the area under the glucose curve (AUC0-120Glucose) and insulin sensitivity index were calculated. A subgroup (n = 494) underwent hyperinsulinaemic-euglycaemic clamp tests. Prolactin associated positively with insulin sensitivity (p = 0.001, adjusted for gender, age, and BMI). Age strongly interacted (p < 0.0001) with the effect of prolactin on insulin sensitivity, inverting the positive relationship to a negative one in younger participants. Glycated haemoglobin (HbA1c) and AUC0-120Glucose correlated negatively with prolactin, and an interaction with age was found as well. Higher prolactin levels are associated with improved insulin sensitivity and lower glucose in individuals without diabetes. This relationship turns to its opposite in younger persons. As prolactin is a proxy for the dopaminergic tone in the central nervous system, these associations may indicate an age-dependent influence of the brain on peripheral insulin sensitivity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Prolactin; Insulin sensitivity; Bromocriptine; Cross-sectional investigation; Interaction with age; Glucose-tolerance; Luteinizing-hormone; Plasma Prolactin; Obese Subjects; Body-weight; Secretion; Bromocriptine; Inhibition; Release; Women
ISSN (print) / ISBN 0940-5429
e-ISSN 1432-5233
Zeitschrift Acta Diabetologica
Quellenangaben Band: 51, Heft: 1, Seiten: 71-78 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Milan
Begutachtungsstatus Peer reviewed