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Kümmel, D.* ; Oeckinghaus, A. ; Wang, C.* ; Krappmann, D. ; Heinemann, U.*

Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells.

FEBS Lett. 582, 3729-3733 (2008)
Open Access Green as soon as Postprint is submitted to ZB.
The transport protein particle (TRAPP) complex is required for proper vesicular transport from the ER to the Golgi. The composition of yeast TRAPP is well characterized, but the organization of mammalian TRAPP complex remains elusive. Using a tandem affinity purification (TAP) approach, we provide first experimental proof for the association of NIBP (NIK/IKKbeta binding protein) with Bet3 and find two human paralogs of Trs33 (A and B) associated with Bet3. Interaction studies and gel filtration analysis reveal that both proteins are part of human TRAPP and might mark two distinct isocomplexes that exert different functions in the regulation of ER-to-Golgi traffic.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Vesicular transport; TRAPP; Golgi; Bet3; Trs33
ISSN (print) / ISBN 0014-5793
e-ISSN 1873-3468
Journal FEBS Letters
Quellenangaben Volume: 582, Issue: 27, Pages: 3729-3733 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed