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Bartis, D.* ; Mise, N. ; Mahida, R.Y.* ; Eickelberg, O. ; Thickett, D.R.*

Epithelial-mesenchymal transition in lung development and disease: Does it exist and is it important?

Thorax 69, 760-765 (2014)
Open Access Green as soon as Postprint is submitted to ZB.
Epithelial-mesenchymal transition (EMT) is a process when epithelial cells gradually transform into mesenchymal-like cells losing their epithelial functionality and characteristics. EMT is thought to be involved in the pathogenesis of numerous lung diseases ranging from developmental disorders, fibrotic tissue remodelling to lung cancer. The most important question-namely what is the importance and contribution of EMT in the pathogenesis of several chronic lung conditions (asthma, COPD, bronchiolitis obliterans syndrome and lung fibrosis)-is currently intensely debated. This review gives a brief insight into the mechanism and assessment methods of EMT in various pulmonary diseases and summarises the recent literature highlighting the controversial experimental data and conclusions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Idiopathic Pulmonary-fibrosis; Growth-factor-beta; Transcription Factor Slug; Smooth-muscle-cells; Tgf-beta; Cigarette-smoke; Extracellular-matrix; Airway; Asthma; Cancer
ISSN (print) / ISBN 0040-6376
e-ISSN 1468-3296
Journal Thorax
Quellenangaben Volume: 69, Issue: 8, Pages: 760-765 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Publishing Place London
Reviewing status Peer reviewed