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Hyperthermia adds to chemotherapy.

Eur. J. Cancer 44, 2546-2554 (2008)
Open Access Green as soon as Postprint is submitted to ZB.
The hallmarks of hyperthermia and its pleotropic effects are in favour of its combined use with chemotherapy. Preclinical research reveals that for heat killing and synergistic effects the thermal dose is most critical. Thermal enhancement of drug cytotoxicity is accompanied by cellular death and necrosis without increasing its oncogenic potential. The induction of genetically defined stress responses can deliver danger signals to activate the host's immune system. The positive results of randomised trials have definitely established hyperthermia in combination with chemotherapy as a novel clinical modality for the treatment of cancer. Hyperthermia targets the action of chemotherapy within the heated tumour region without affecting systemic toxicity. In specific clinical settings regional hyperthermia (RHT) or hyperthermic perfusion has proved its value and deserve a greater focus and investigation in other malignancies. In Europe, more specialised centres should be created and maintained as network of excellence for hyperthermia in the field of oncology.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hyperthermia; Chemotherapy; HSP; Immunology; Liposomes; HIPEC; ILP
ISSN (print) / ISBN 0959-8049
e-ISSN 1879-0852
Quellenangaben Volume: 44, Issue: 17, Pages: 2546-2554 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed