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Abbas, S.* ; Linseisen, J. ; Rohrmann, S.* ; Beulens, J.W.J.* ; Buijsse, B.* ; Amiano, P.* ; Ardanaz, E.* ; Balkau, B.* ; Boeing, H.* ; Clavel-Chapelon, F.* ; Fagherazzi, G.* ; Franks, P.W.* ; Gavrila, D.* ; Grioni, S.* ; Kaaks, R.* ; Key, T.J.* ; Khaw, K.T.* ; Kuhn, T.* ; Mattiello, A.* ; Molina-Montes, E.* ; Nilsson, P.M.* ; Overvad, K.* ; Quirós, J.R.* ; Rolandsson, O.* ; Sacerdote, C.* ; Saieva, C.* ; Slimani, N.* ; Sluijs, I.* ; Spijkerman, A.M.W.* ; Tjonneland, A.* ; Tumino, R.* ; van der A, D.L.* ; Zamora-Ros, R.* ; Sharp, S.J.* ; Langenberg, C.* ; Forouhi, N.G.* ; Riboli, E.* ; Wareham, N.J.*

Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study.

Eur. J. Clin. Nutr. 68, 196-202 (2014)
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Background/Objectives: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. Subjects/Methods: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N=15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires. Results: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (Ptrend =0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D. Conclusions: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Vitamin D ; Type 2 Diabetes ; Dietary Intake ; Observational Study ; Epic; 25-hydroxyvitamin D Concentration; Health Report 2004; Insulin-secretion; 1,25-dihydroxyvitamin D-3; Calcium; Metaanalysis; Calibration; Cohort; Women; Expression
ISSN (print) / ISBN 0954-3007
e-ISSN 1476-5640
Quellenangaben Band: 68, Heft: 2, Seiten: 196-202 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed