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Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies.

Oncogene 33, 5655-5665 (2014)
Postprint DOI
Open Access Green
The discovery of constitutive nuclear factor-κB (NF-κB) activation in Hodgkin's lymphoma tumor cells almost two decades ago was one of the first reports that directly connected deregulated NF-κB signaling to human cancer. Subsequent studies demonstrated that enhanced NF-κB signaling is a common hallmark of many lymphoid malignancies, including Hodgkin lymphoma, mucosa-associated lymphoid tissue lymphoma, diffuse large B-cell lymphoma and multiple myeloma. By inducing an anti-apoptotic and pro-proliferative gene program, NF-κB is involved in lymphoma survival and growth. Identification of somatic mutations that led to activation of oncogenes and inactivation of tumor suppressor genes in the pathway revealed that specific pathogenic mechanisms are responsible for constitutive NF-κB activation in different lymphoma entities. Thus, the identification of distinct oncogenic events is reflecting the diverse cellular origins of the different lymphomas. Further, elucidation of the mechanisms that drive NF-κB in lymphoma is of high clinical relevance as it will allow the design of target-directed precision therapy. Indeed, a number of drugs that impair constitutive NF-κB activation in lymphoid malignancies are currently in preclinical or clinical development.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Nf-kappa B Signaling ; Hodgkin's Lymphoma ; Malt Lymphoma ; Dlbcl ; Multiple Myeloma
ISSN (print) / ISBN 0950-9232
e-ISSN 0950-9232
Journal Oncogene
Quellenangaben Volume: 33, Issue: 50, Pages: 5655-5665 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed