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März, M.* ; Beerenwinkel, N.* ; Drosten, C.* ; Fricke, M.* ; Frishman, D. ; Hofacker, I.L.* ; Hoffmann, D.* ; Middendorf, M.* ; Rattei, T.* ; Stadler, P.F.* ; Töpfer, A.*

Challenges in RNA virus bioinformatics.

Bioinformatics 30, 1793-1799 (2014)
Verlagsversion Volltext DOI PMC
Open Access Gold
Computer-assisted studies of structure, function, and evolution of viruses remains a neglected area of research. The attention of bioinformaticians to this interesting and challenging field is far from commensurate with its medical and biotechnological importance. It is very telling that out of over 200 talks held at ISMB 2013, the largest international bioinformatics conference, only one presentation explicitly dealt with viruses. In contrast to many broad, established and well organized bioinformatics communities (e.g. structural genomics, ontologies, next-generation sequencing, expression analysis), research groups focusing on viruses can probably be counted on the fingers of two hands. The purpose of this review is to increase awareness among bioinformatics researchers about the pressing needs and unsolved problems of computational virology. We focus primarily on RNA viruses that pose problems to many standard bioinformatics analyses due to their compact genome organization, fast mutation rate, and low evolutionary conservation. We provide an overview of tools and algorithms for handling viral sequencing data, detecting functionally important RNA structures, classifying viral proteins into families, and investigating the origin and evolution of viruses.
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
e-ISSN 1367-4811
Zeitschrift Bioinformatics
Quellenangaben Band: 30, Heft: 13, Seiten: 1793-1799 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)
POF Topic(s) 30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503700-001
PubMed ID 24590443
DOI 10.1093/bioinformatics/btu105
WOS ID WOS:000339121900001
Scopus ID 84903693951
Erfassungsdatum 2014-03-13
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