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Schilling, F.* ; Warner, L.R. ; Gershenzon, N.I.* ; Skinner, T.E.* ; Sattler, M. ; Glaser, S.J.*

Next-generation heteronuclear decoupling for high-field biomolecular NMR spectroscopy.

Angew. Chem.-Int. Edit. 53, 4475-4479 (2014)
Open Access Green as soon as Postprint is submitted to ZB.
Ultra-high-field NMR spectroscopy requires an increased bandwidth for heteronuclear decoupling, especially in biomolecular NMR applications. Composite pulse decoupling cannot provide sufficient bandwidth at practical power levels, and adiabatic pulse decoupling with sufficient bandwidth is compromised by sideband artifacts. A novel low-power, broadband heteronuclear decoupling pulse is presented that generates minimal, ultra-low sidebands. The pulse was derived using optimal control theory and represents a new generation of decoupling pulses free from the constraints of periodic and cyclic sequences. In comparison to currently available state-of-the-art methods this novel pulse provides greatly improved decoupling performance that satisfies the demands of high-field biomolecular NMR spectroscopy.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Decoupling Sidebands ; Nmr Spectroscopy ; Nucleic Acids ; Proteins ; Ultra-broadband Decoupling; Magnetic-resonance-spectroscopy; Optimal-control Design; Broad-band; Adiabatic Pulses; Resolution; Excitation; Inversion; Reconstruction; Acquisition; Calibration
ISSN (print) / ISBN 1433-7851
e-ISSN 1521-3773
Quellenangaben Volume: 53, Issue: 17, Pages: 4475-4479 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed