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Increased amino acids levels and the risk of developing hypertriglyceridemia in a 7-year follow-up.

J. Endocrinol. Invest. 37, 369-374 (2014)
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Background Recently, five branched-chain and aromatic amino acids were shown to be associated with the risk of developing type 2 diabetes (T2D). Aim We set out to examine whether amino acids are also associated with the development of hypertriglyceridemia. Materials and methods We determined the serum amino acids concentrations of 1,125 individuals of the KORA S4 baseline study, for which follow-up data were available also at the KORA F4 7 years later. After exclusion for hypertriglyceridemia (defined as having a fasting triglyceride level above 1.70 mmol/L) and diabetes at baseline, 755 subjects remained for analyses. Results Increased levels of leucine, arginine, valine, proline, phenylalanine, isoleucine and lysine were significantly associated with an increased risk of hypertriglyceridemia. These associations remained significant when restricting to those individuals who did not develop T2D in the 7-year follow-up. The increase per standard deviation of amino acid level was between 26 and 40 %. Conclusions Seven amino acids were associated with an increased risk of developing hypertriglyceridemia after 7 years. Further studies are necessary to elucidate the complex role of these amino acids in the pathogenesis of metabolic disorders.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Amino acids; Hypertriglyceridemia; Insulin-resistance; Cardiovascular-disease; Heart-disease; Acylcarnitines; Population; Metabolism; Obesity; Humans; Kora
ISSN (print) / ISBN 0391-4097
e-ISSN 1720-8386
Quellenangaben Volume: 37, Issue: 4, Pages: 369-374 Article Number: , Supplement: ,
Publisher Springer
Publishing Place New York
Reviewing status Peer reviewed