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Longitudinal changes in health-related quality of life in normal glucose tolerance, prediabetes and type 2 diabetes: Results from the KORA S4/F4 cohort study.

Qual. Life Res. 23, 2515-2520 (2014)
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PURPOSE: The aim of this study was to examine how transition between normal glucose tolerance, prediabetes and diabetes over a 7 year period is associated with change in health-related quality of life (HRQL) in an elder German population-based cohort. METHODS: We used data from 1,046 participants of the KORA S4/F4 cohort study aged 55-74 years at baseline. Based on an oral glucose tolerance test, prediabetes was defined as impaired fasting glucose and/or impaired glucose tolerance. HRQL was assessed with the SF-12 questionnaire. Using linear regression, we estimated mean change in HRQL over time, depending on glucose status at baseline and follow-up, adjusted by demographic and lifestyle variables. RESULTS: Individuals progressing to prediabetes or diabetes experienced a greater loss in the physical component score than patients with persistent normal glucose tolerance (-2.31 and -7.44 vs. -1.08), but the difference was only significant for subjects converting to diabetes. Subjects with prediabetes at baseline and diabetes at follow-up had a significant loss in mental health compared to subjects with persistent prediabetes. CONCLUSIONS: There is first evidence that worsening of glucose metabolism over time is associated with deteriorating HRQL, however, further and larger longitudinal studies are needed to confirm these findings.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Diabetes ; Health Services Research ; Health Status ; Impaired Glucose Tolerance ; Longitudinal Studies ; Prediabetes ; Quality Of Life; Older Population; Metabolism; Prevalence; Mellitus; Depression; Obesity; Adults; Risk; Metaanalysis; Association
ISSN (print) / ISBN 0962-9343
e-ISSN 1573-2649
Quellenangaben Volume: 23, Issue: 9, Pages: 2515-2520 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Dordrecht
Reviewing status Peer reviewed