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Ketterer, C. ; Heni, M.* ; Stingl, K.T.* ; Tschritter, O.* ; Linder, K. ; Wagner, R.* ; Machicao, F. ; Häring, H.-U. ; Preissl, H. ; Staiger, H. ; Fritsche, A.

Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action.

Obesity 22, 925-931 (2014)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Objective: The cannabinoid-receptor system is involved in the regulation of food intake. Here, we test whether single nucleotide polymorphisms (SNPs) in CNR2, encoding the cannabinoid-receptor 2, are associated with weight in a cross-sectional cohort. Furthermore, we wanted to investigate if the identified hits influence weight loss during lifestyle intervention; and study a potential involvement of cerebral insulin action. Methods: 2006 subjects at increased risk for type 2 diabetes mellitus were genotyped for 5 tagging SNPs in the CNR2 locus. All subjects underwent a 75-g OGTT. 345 subjects participated in a lifestyle intervention (TUebingen Lifestyle Intervention Programme). Cerebrocortical insulin sensitivity was measured by magnetoencephalography after intranasal insulin application in 43 subjects. Results: In the cross-sectional cohort, the minor allele of rs3123554 was associated with lower BMI (P-add = 0.01, P-rec = 0.004), and this was attributable to its effect in women only. Interestingly, during lifestyle intervention, carriers of the same allele lost less body weight (P-add = 0.03, P-rec = 0.008). Moreover, carriers of this minor allele showed lower cerebral insulin sensitivity (P-rec = 0.0402). Conclusions: The minor allele of rs3123554 is associated cross-sectionally with lower body weight, whereas during intervention the same allele led to less reduction of body weight. Reduced cerebral insulin sensitivity in carriers of this allele might contribute to these disadvantageous effects during lifestyle intervention.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Life-style Intervention; Impaired Glucose-tolerance; Cannabinoid Cb2 Receptors; Diabetes Prevention; Food-intake; Fto Gene; Brain; Activation; Humans; System
ISSN (print) / ISBN 1930-7381
e-ISSN 1930-739X
Zeitschrift Obesity
Quellenangaben Band: 22, Heft: 3, Seiten: 925-931 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed