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Moreth, K. ; Fischer, R. ; Fuchs, H. ; Gailus-Durner, V. ; Wurst, W. ; Katus, H.A.* ; Bekeredjian, R.* ; Hrabě de Angelis, M.

High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains.

J. Comp. Physiol. B 184, 763-775 (2014)
Verlagsversion Volltext DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mice with genetic alterations are used in heart research as model systems of human diseases. In the last decade there was a marked increase in the recognition of genetic diversity within inbred mouse strains. Increasing numbers of inbred mouse strains and substrains and analytical variation of cardiac phenotyping methods require reproducible, high-throughput methods to standardize murine cardiovascular physiology. We describe methods for non-invasive, reliable, easy and fast to perform echocardiography and electrocardiography on awake mice. This method can be used for primary screening of the murine cardiovascular system in large-scale analysis. We provide insights into the physiological divergence of C57BL/6N, C57BL/6J, C3HeB/FeJ and 129P2/OlaHsd mouse hearts and define the expected normal values. Our report highlights that compared to the other three strains tested C57BL/6N hearts reveal features of heart failure such as hypertrophy and reduced contractile function. We found several features of the mouse ECG to be under genetic control and obtained several strain-specific differences in cardiac structure and function.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter C57bl/6 ; Echocardiography ; Electrocardiography ; Heart ; Screening; Left-ventricular Function; Integrin-linked Kinase; Heart-rate; Echocardiographic-assessment; Dilated Cardiomyopathy; Conduction System; Gene-expression; Deficient Mice; Interval; Electrocardiogram
ISSN (print) / ISBN 0174-1578
e-ISSN 1432-136X
Quellenangaben Band: 184, Heft: 6, Seiten: 763-775 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Heidelberg
Begutachtungsstatus Peer reviewed