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Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies.
Antioxid. Redox Signal. 12, 851-865 (2010)
Selenium (Se), in the form of the 21st amino acid selenocysteine, is an integral part of selenoproteins and essential for mammals. While a large number of health claims for Se has been proposed in a diverse set of diseases, little is known about the precise molecular mechanisms and the physiological roles of selenoproteins. With the recent and rigorous application of reverse genetics in the mouse, great strides have been made to address this on a more molecular level. In this review, we focus on results obtained from the application of mouse molecular genetics in mouse physiology and discuss these insights into the physiological actions of selenoproteins in light of evidence from human genetics.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hydroperoxide glutathione-peroxidase; Selenocydteine transfer-RNA; Deficient transgenic mice; Early embryonic lethality; Cancer prevention trail; Whole-body selenium; Selenoprotein-P; Thioredoxin reductase; Targeted disruption; Oxidative stress
ISSN (print) / ISBN 1523-0864
Journal Antioxidants & Redox Signaling
Quellenangaben Volume: 12, Issue: 7, Pages: 851-865
Publisher Mary Ann Liebert
Reviewing status Peer reviewed