PuSH - Publication Server of Helmholtz Zentrum München

Shin, S.Y.* ; Fauman, E.B.* ; Petersen, A.-K. ; Krumsiek, J. ; Santos, R.* ; Huang, J.* ; Arnold, M. ; Erte, I.* ; Forgetta, V.* ; Yang, T.P.* ; Walter, K.* ; Menni, C.* ; Chen, L.* ; Vasquez, L.* ; Valdes, A.M.* ; Hyde, C.L.* ; Wang, V.* ; Ziemek, D.* ; Roberts, P.* ; Xi, L.* ; Grundberg, E.* ; Waldenberger, M. ; Richards, J.B.* ; Mohney, R.P.* ; Milburn, M.V.* ; John, S.L.* ; Trimmer, J.* ; Theis, F.J. ; Overington, J.P.* ; Suhre, K. ; Brosnan, M.J.* ; Gieger, C. ; Kastenmüller, G. ; Spector, T.D.* ; Soranzo, N.*

An atlas of genetic influences on human blood metabolites.

Nat. Genet. 46, 543-550 (2014)
Open Access Green as soon as Postprint is submitted to ZB.
Genome-wide association scans with high-throughput metabolic profiling provide unprecedented insights into how genetic variation influences metabolism and complex disease. Here we report the most comprehensive exploration of genetic loci influencing human metabolism thus far, comprising 7,824 adult individuals from 2 European population studies. We report genome-wide significant associations at 145 metabolic loci and their biochemical connectivity with more than 400 metabolites in human blood. We extensively characterize the resulting in vivo blueprint of metabolism in human blood by integrating it with information on gene expression, heritability and overlap with known loci for complex disorders, inborn errors of metabolism and pharmacological targets. We further developed a database and web-based resources for data mining and results visualization. Our findings provide new insights into the role of inherited variation in blood metabolic diversity and identify potential new opportunities for drug development and for understanding disease.
Additional Metrics?
Icb_InKoMBio_CellComm Icb_metabo Icb_MIMOmics Icb_ML
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association; Profiles; Variants
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 46, Issue: 6, Pages: 543-550 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed