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Friedrich, N.* ; Wolthers, O.D.* ; Arafat, A.M.* ; Emeny, R.T. ; Spranger, J.* ; Roswall, J.* ; Kratzsch, J.* ; Grabe, H.J.* ; Hübener, C.* ; Pfeiffer, A.F.H.* ; Döring, A. ; Bielohuby, M.* ; Dahlgren, J.* ; Frystyk, J.J.* ; Wallaschofski, H.* ; Bidlingmaier, M.*

Age- and sex-specific reference intervals across life span for Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) and the IGF-i to IGFBP-3 ratio measured by new automated chemiluminescence assays.

J. Clin. Endocrinol. Metab. 99, 1675-1686 (2014)
Open Access Green as soon as Postprint is submitted to ZB.
Context: Measurement of IGF-binding protein-3 (IGFBP-3) can aid the diagnosis of GH-related diseases. Furthermore, epidemiological studies suggest that IGFBP-3 and the molar IGF-I to IGFBP-3 ratio are associated with clinical end points like cancer or cardiovascular disease. However, their clinical use is limited by the lack of validated reference intervals. Objective: The objective of the study was the establishment of age- and sex-specific reference intervals for IGFBP-3 and the molar IGF-I to IGFBP-3 ratio by newly developed automated immunoassays. Setting: This was a multicenter study with samples from 11 cohorts from the United States, Canada, and Europe. Participants: A total of 14 970 healthy subjects covering all ages from birth to senescence participated in the study. Main Outcome Measures: Concentrations of IGFBP-3 and the IGF-I to IGFBP-3 ratio as determined by the IDS iSYS IGF-I and IGFBP-3 assays were measured. Results: Both the concentration of IGFBP-3 and the IGF-I to IGFBP-3 ratio are mainly determined by age. IGFBP-3 concentrations increase until the age of 22 years, with a plateau being visible between 15 and 25 years. Determined by the high peripubertal peak in IGF-I, the peak in the IGF-I to IGFBP-3 ratio occurs already around the age of 15 years, with a slightly earlier and higher peak in females. Beyond the age of 60 years, IGFBP-3 concentrations remain higher in females, whereas IGF-I as well as the IGF-I to IGFBP-3 ratio remains significantly higher in males. Conclusions: We present an extensive set of assay-specific age- and sex-adjusted normative data for concentrations of IGFBP-3 and the molar IGF-I to IGFBP-3 ratio and demonstrate distinct sex specific differences across the life span.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Population-based Sample; Serum-levels; Reference Ranges; Reference Values; Factor (igf)-i; Glucose-homeostasis; Clinical-practice; Adult-population; Pomerania Ship; Hormone
ISSN (print) / ISBN 0021-972X
e-ISSN 1945-7197
Quellenangaben Volume: 99, Issue: 5, Pages: 1675-1686 Article Number: , Supplement: ,
Publisher Endocrine Society
Publishing Place Bethesda, Md.
Reviewing status Peer reviewed