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Methods Mol. Biol. 609, 385-400 (2010)
Obtaining well-diffracting crystals remains a major challenge in protein structure research. In this chapter, we review currently available computational methods to estimate the crystallization potential of a protein, to optimize amino acid sequences toward improved crystallization likelihood, and to design optimal crystal screen conditions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords protein crystallization; construct optimization; crystallization conditions, crystallization screen