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Metabolic profiling in diabetes.
J. Endocrinol. 221, R75-R85 (2014)
Metabolic profiling, or metabolomics, has developed into a mature science in recent years. It has major applications in the study of metabolic disorders. This review addresses issues relevant to the choice of the metabolomics platform, study design and data analysis in diabetes research, and presents recent advances using metabolomics in the identification of markers for altered metabolic pathways, biomarker discovery, challenge studies, metabolic markers of drug efficacy and off-target effects. The role of genetic variance and intermediate metabolic phenotypes and its relevance to diabetes research is also addressed.
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Publication type Article: Journal article
Document type Review
Keywords Diabetes ; Glucose Metabolism ; Insulin Resistance ; Lipid ; Metabolism; Multivariate Statistical-analysis; Chain Amino-acids; Insulin-resistance; Mass-spectrometry; Wide Association; Genome-wide; Serum 1,5-anhydroglucitol; Quantitative-analysis; Plasma Metabolomics; Glucose Challenge
ISSN (print) / ISBN 0022-0795
Journal Journal of Endocrinology
Quellenangaben Volume: 221, Issue: 3, Pages: R75-R85
Publisher Society for Endocrinology
Publishing Place Bristol
Reviewing status Peer reviewed