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Monocyte subsets in man and other species.

Cell. Immunol. 289, 135-139 (2014)
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Monocytes are white blood cells that belong to the mononuclear phagocyte system. They derive from precursors in bone marrow, from there they go into blood, where they have a half-life of 1-2 days, and then they migrate into the various tissues. Monocyte subsets were discovered by means of flow cytometry in human blood some 20years ago and their phenotype and function has been characterized in detail in health and disease. The subset classification as classical, intermediate and non-classical monocytes appears to apply to other species as well, as reviewed in here by comparing data on human monocytes with the respective cells in the mouse, the rat, the pig, the cow and the horse. The data show that the subsets are homologous between the species but there are important differences in subset-specific gene expression such that findings in a given species cannot be directly translated to man.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Innate Immunity; Colony-stimulating Factor; Blood Monocytes; Monoclonal-antibodies; Nonhuman-primates; Cd14(+)cd16(+) Monocytes; Peripheral-blood; Dendritic Cells; In-vivo; Expression; Subpopulations
ISSN (print) / ISBN 0008-8749
e-ISSN 0008-8749
Quellenangaben Volume: 289, Issue: 1-2, Pages: 135-139 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place San Diego
Reviewing status Peer reviewed