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Kastl, M. ; Giussani, A.* ; Blanchardon, E.* ; Breustedt, B.* ; Fritsch, P.* ; Hoeschen, C. ; López, M.A.*

Developing a physiologically based approach for modeling plutonium decorporation therapy with DTPA.

Int. J. Radiat. Biol. 90, 1062-1067 (2014)
Postprint Pre-Print DOI
Open Access Green
Abstract Purpose: To develop a physiologically based compartmental approach for modeling plutonium decorporation therapy with the chelating agent Diethylenetriaminepentaacetic acid (Ca-DTPA/Zn-DTPA). Materials and methods: Model calculations were performed using the software package SAAM II (©The Epsilon Group, Charlottesville, Virginia, USA). The Luciani/Polig compartmental model with age-dependent description of the bone recycling processes was used for the biokinetics of plutonium. Results: The Luciani/Polig model was slightly modified in order to account for the speciation of plutonium in blood and for the different affinities for DTPA of the present chemical species. The introduction of two separate blood compartments, describing low-molecular-weight complexes of plutonium (Pu-LW) and transferrin-bound plutonium (Pu-Tf) respectively, and one additional compartment describing plutonium in the interstitial fluids was performed successfully. Conclusions: The next step of the work is the modeling of the chelation process, coupling the physiologically modified structure with the biokinetic model for DTPA. Results of animal studies performed under controlled conditions will enable to better understand the principles of the involved mechanisms.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Chelation ; Dtpa ; Actinides ; Biokinetic Modeling ; Decorporation ; Plutonium
ISSN (print) / ISBN 0955-3002
e-ISSN 1362-3095
Quellenangaben Volume: 90, Issue: 11, Pages: 1062-1067 Article Number: , Supplement: ,
Publisher Informa Healthcare
Reviewing status Peer reviewed