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Response to comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".

Science 344:1237 (2014)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Letter to the Editor
Schlagwörter Infection; Cells; Mice
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 344, Heft: 6189, Seiten: , Artikelnummer: 1237 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington
Begutachtungsstatus Peer reviewed