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Use of metabolomics and proteomics to reveal pathophysiological pathways in anxiety disorders.

Adv. Biol. Psychiatry 29, 128-138 (2014)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
With a frequent occurrence of approximately 10.6% in adult populations, anxiety disorders are among the most common mental health problems worldwide. Although anxiety disorders are rather prevalent, their underlying biochemical mechanisms remain unclear. As a functional endpoint of all biological events, the metabolome represents the most precise and direct molecular expression of a phenotype. Combining metabolic information with proteome data, systems biology can draw an even more comprehensive picture of the biological processes. Here, we provide a review summarizing the results from human as well as animal studies analyzing metabolic and proteomic traits in different tissues for associations with anxiety. In addition, we give an overview of animal studies that applied a systems biology approach using metabolic as well as proteomic data to identify anxiety-related pathways.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0378-7354
e-ISSN 1662-2774
Conference Title Proteomics and Metabolomics in Psychiatry
Quellenangaben Volume: 29, Issue: , Pages: 128-138 Article Number: , Supplement: ,
Publisher Karger
Publishing Place Basel [u.a.]
Reviewing status Peer reviewed