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Möller, W. ; Schuschnig, U.* ; Bartenstein, P.* ; Meyer, G.* ; Häussinger, K.* ; Schmid, O. ; Becker, S.*

Drug delivery to paranasal sinuses using pulsating aerosols.

J. Aerosol Med. Pulm. Drug Deliv. 27, 255-263 (2014)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Abstract Chronic rhinosinusitis (CRS) is the major disorder of the upper airways, affecting about 10-15% of the total population. Topical treatment regimens show only modest efficacy, because drug delivery to the posterior nose and paranasal sinuses is still a challenge. Therefore, there is a high rate of functional endoscopic sinus surgery in CRS patients. Most nasally administered aerosolized drugs, like nasal pump sprays, are efficiently filtered by the nasal valve and do not reach the posterior nasal cavity and the sinuses, which are poorly ventilated. However, as highlighted in this review, sinus ventilation and paranasal aerosol delivery can be achieved by using pulsating airflow, offering new topical treatment options for nasal disorders. Radioaerosol inhalation and imaging studies in nasal casts and in healthy volunteers have shown 4-6% of the nasally administered dose within the sinuses. In CRS patients, significant aerosol deposition in the sinus cavities was reported before sinus surgery. After surgery, deposition increased to the amount observed in healthy volunteers. In addition, compared with nasal pump sprays, retention kinetics of the radiolabel deposited in the nasal cavity was prolonged, both in healthy volunteers and in CRS patients. These efficiencies may be sufficient for topical aerosol therapies of sinus disorders and, due to the prolonged retention kinetics, may reduce application modes, but have to be proven in future clinical trials. Pulsating aerosols may offer additional new topical treatment options of nasal and sinus disorders before as well as after surgery.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Chronic Rhinosinusitis ; Clearance ; Paranasal Sinus Ventilation ; Pulsating Aerosol ; Topical Therapy; Chronic Rhinosinusitis; Cystic-fibrosis; Air-flow; Nasal Irrigation; Controlled-trial; Disease; Sinusitis; Asthma; Ventilation; Inhalation
ISSN (print) / ISBN 0894-2684
e-ISSN 1557-9026
Zeitschrift Journal of Aerosol Medicine and Pulmonary Drug Delivery
Quellenangaben Band: 27, Heft: 4, Seiten: 255-263 Artikelnummer: , Supplement: ,
Verlag Mary Ann Liebert
Verlagsort New Rochelle
Begutachtungsstatus