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Estimation of optoacoustic contrast agent concentration with self-calibration blind logarithmic unmixing.

Phys. Med. Biol. 59, 4785-4797 (2014)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Chromophore quantification in optoacoustic tomography is challenging due to signal contributions from strongly absorbing background tissue chromophores and the depth-dependent light attenuation. Herein we present a procedure capable of correcting for wavelength-dependent light fluence variations using a logarithmic representation of the images taken at different wavelengths assisted with a blind unmixing approach. It is shown that the serial expansion of the logarithm of an optoacoustic image contains a term representing the ratio between absorption of the probe of interest and other background components. Under assumptions of tissue-like background absorption variations, this term can be readily isolated with an unmixing algorithm, attaining quantitative maps of photo-absorbing agent distribution.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Multispectral Unmixing ; Optoacoustic Probes ; Optoacoustic Tomography ; Quantitative Imaging; In-vivo; Reconstruction Algorithm; Photoacoustic Microscopy; Scattering Media; High-resolution; Tomography
ISSN (print) / ISBN 0031-9155
e-ISSN 1361-6560
Quellenangaben Band: 59, Heft: 17, Seiten: 4785-4797 Artikelnummer: , Supplement: ,
Verlag Institute of Physics Publishing (IOP)
Verlagsort Bristol
Begutachtungsstatus Peer reviewed