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New pharmacological strategies to fight enveloped viruses.

Trends Pharmacol. Sci. 35, 470-478 (2014)
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Open Access Green as soon as Postprint is submitted to ZB.
Enveloped viruses pose an important health threat because most of the persistent and many emerging viruses are enveloped. In particular, newly emerging viruses create a need to develop broad-spectrum antivirals, which usually are obtained by targeting host cell factors. Persistent viruses have developed efficient strategies to escape host immune control, and treatment options are limited. Targeting host cell factors essential for virus persistence, or immune-based therapies provide alternative approaches. In this review, we therefore focus on recent developments to generate antivirals targeting host cell factors or immune-based therapeutic approaches to fight infections with enveloped viruses.
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Publication type Article: Journal article
Document type Review
Keywords Antiviral Agents ; Emerging Disease ; Host Cell Factors ; Immunotherapy; Human-immunodeficiency-virus; Hepatitis-b; Monoclonal-antibodies; Human Cytomegalovirus; Hcv Infection; Cells; Inhibitors; Entry; Diseases; Receptor
ISSN (print) / ISBN 0165-6147
e-ISSN 1873-3735
Quellenangaben Volume: 35, Issue: 9, Pages: 470-478 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Amsterdam
Reviewing status Peer reviewed