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Vegiopoulos, A.* ; Müller-Decker, K.* ; Strzoda, D.* ; Schmitt, I.* ; Chichelnitskiy, E.* ; Ostertag, A.* ; Berriel Diaz, M.* ; Rozman, J. ; Hrabě de Angelis, M.* ; Nüsing, R.M.* ; Meyer, C.W.* ; Wahli, W.* ; Klingenspor, M.* ; Herzig, S.*

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.

Science 328, 1158-1161 (2010)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Obesity results from chronic energy surplus and excess lipid storage in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive thermogenesis. Studying mouse models, we show that cyclooxygenase (COX)-2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of beta-adrenergic signaling in WAT and is required for the induction of BAT in WAT depots. PG shifted the differentiation of defined mesenchymal progenitors toward a brown adipocyte phenotype. Overexpression of COX-2 in WAT induced de novo BAT recruitment in WAT, increased systemic energy expenditure, and protected mice against high-fat diet-induced obesity. Thus, COX-2 appears integral to de novo BAT recruitment, which suggests that the PG pathway regulates systemic energy homeostasis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adipose-tissue; Prar-gamma; Identification; Receptor; Fat; Celecoxib; Obesity; PRDM16
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 328, Heft: 5982, Seiten: 1158-1161 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Begutachtungsstatus Peer reviewed