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Taruttis, A. ; Lozano, N.* ; Nunes, A. ; Jasim, D.A.* ; Bézière, N. ; Herzog, E. ; Kostarelos, K.* ; Ntziachristos, V.

siRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics.

Nanoscale 6, 13451-13456 (2014)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Therapeutic applications of gene silencing using siRNA have seen increasing interest over the past decade. The optimization of the delivery and biodistribution of siRNA using liposome-gold nanorod (AuNRs) nanoscale carriers can greatly benefit from adept imaging methods that can visualize the time-resolved delivery performance of such vectors. In this work, we describe the effect of AuNR length incorporated with liposomes and show their complexation with siRNA as a novel gene delivery vehicle. We demonstrate the application of multispectral optoacoustic tomography (MSOT) to longitudinally visualize the localisation of siRNA carrying liposome-AuNR hybrids within tumors. Combination of in vivo MSOT with ex vivo fluorescence cryo-slice imaging offers further insight into the siRNA transport and activity obtained.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 2040-3364
e-ISSN 2040-3372
Journal Nanoscale
Quellenangaben Volume: 6, Issue: 22, Pages: 13451-13456 Article Number: , Supplement: ,
Publisher Royal Society of Chemistry (RSC)
Publishing Place Cambridge
Reviewing status Peer reviewed