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Kobori, M.* ; Yang, Z.* ; Gong, D.* ; Heissmeyer, V.* ; Zhu, H.* ; Jung, Y.K.* ; Gakidis, M.A.* ; Rao, A.* ; Sekine, T.* ; Ikegami, F.* ; Yuan, C.* ; Yuan, J.*

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex.

Cell Death Differ. 11, 123-30 (2004)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Caspase-11 is a key regulator of proinflammatory cytokine IL-1beta maturation and pathological apoptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological stimulation such as in the presence of lipopolysaccharide (LPS). Here, we describe the identification and characterization of wedelolactone, a natural compound that inhibits LPS-induced caspase-11 expression in cultured cells by inhibiting NF-kappaB-mediated transcription. We demonstrate that wedelolactone is an inhibitor of IKK, a kinase critical for activation of NF-kappaB by mediating phosphorylation and degradation of IkappaBalpha.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 1350-9047
e-ISSN 1476-5403
Quellenangaben Band: 11, Heft: 1, Seiten: 123-30 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Begutachtungsstatus Peer reviewed