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An approximative approach for single cell spatial modeling of quorum sensing.

J. Comput. Biol. 22, 227-235 (2015)
Publ. Version/Full Text DOI
Open Access Green as soon as Postprint is submitted to ZB.
Abstract Quorum sensing, a special kind of cell-cell communication, has originally been described for well-mixed homogeneous bacterial cultures. However, recent perception supports its ecological relevance for spatially heterogeneous distributed cells, like colonies and biofilms. New experimental techniques allow for single cell analysis under these conditions, which is crucial to understanding the effect of chemical gradients and intercell variations. Based on a reaction-diffusion system, we develop a method that drastically reduces the computational complexity of the model. In comparison to similar former approaches, handling and scaling is much easier. Via a suitable scaling, this approach leads to approximative algebraic equations for the stationary case. This approach can be easily used for numerical situations.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Algorithms ; Computational Molecular Biology ; Evolution; Diffusion
ISSN (print) / ISBN 1066-5277
e-ISSN 1557-8666
Quellenangaben Volume: 22, Issue: 3, Pages: 227-235 Article Number: , Supplement: ,
Publisher Mary Ann Liebert
Publishing Place New Rochelle
Reviewing status