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Bohne, F.* ; Protzer, U.

Adoptive T-cell therapy as a therapeutic option for chronic hepatitis B.

J. Viral Hepat. 14, (Suppl.1), 45-50 (2007)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The human hepatitis B virus is a small, enveloped and non-cytopathic virus, with a very narrow host range and a strong liver tropism causing acute and chronic liver disease. Although a well-tolerated vaccine is available, more than 350 million people are chronically infected worldwide. Available therapies for chronic hepatitis B only rarely eliminate the virus. Although new antivirals are being developed, long-term treatment is required, which may be limited by the selection of resistant viruses. Therefore, immunotherapies are investigated as an approach to eliminate persistently infected cells. Besides therapeutic vaccination, adoptive T-cell therapy is an interesting option, which is discussed in this review.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter adoptive T-cell transfer; chimeric TCR; HBV; T-cell receptor
ISSN (print) / ISBN 1352-0504
e-ISSN 1365-2893
Quellenangaben Band: 14, Heft: , Seiten: 45-50, Artikelnummer: , Supplement: (Suppl.1)
Verlag Wiley
Begutachtungsstatus Peer reviewed