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Zeiser, S. ; Franz, U.* ; Wittich, O.* ; Liebscher, V.*

Simulation of genetic networks modelled by piecewise deterministic Markov processes.

IET Syst. Biol. 2, 113-135 (2008)
Open Access Green as soon as Postprint is submitted to ZB.
The authors propose piecewise deterministic Markov processes as an alternative approach to model gene regulatory networks. A hybrid simulation algorithm is presented and discussed, and several standard regulatory modules are analysed by numerical means. It is shown that despite of the partial simplification of the mesoscopic nature of regulatory networks such processes are suitable to reveal the intrinsic noise effects because of the low copy numbers of genes.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1751-8849
e-ISSN 1751-8857
Quellenangaben Volume: 2, Issue: 3, Pages: 113-135 Article Number: , Supplement: ,
Publisher Institution of Engineering and Technology (IET)
Reviewing status Peer reviewed