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Gudbjartsson, D.F.* ; Holm, H.* ; Gretarsdottir, S.* ; Thorleifsson, G.* ; Walters, G.B.* ; Thorgeirsson, G.* ; Gulcher, J.* ; Mathiesen, E.B.* ; Njølstad, I.* ; Nyrnes, A.* ; Wilsgaard, T.* ; Hald, E.M.* ; Hveem, K.* ; Stoltenberg, C.* ; Kucera, G.* ; Stubblefield, T.* ; Carter, S.* ; Roden, D.* ; Ng, M.C.* ; Baum, L.* ; So, W.Y.* ; Wong, K.S.* ; Chan, J.C.* ; Gieger, C. ; Wichmann, H.-E. ; Gschwendtner, A.* ; Dichgans, M.* ; Kuhlenbäumer, G.* ; Berger, K.* ; Ringelstein, E.B.* ; Bevan, S.* ; Markus, H.S.* ; Kostulas, K.* ; Hillert, J.* ; Sveinbjörnsdóttir, S.* ; Valdimarsson, E.M.* ; Løchen, M.L.* ; Ma, R.C.* ; Darbar, D.* ; Kong, A.* ; Arnar, D.O.* ; Thorsteinsdottir, U.* ; Stefansson, K.*

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.

Nat. Genet. 41, 876-878 (2009)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 41, Issue: 8, Pages: 876-878 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed