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Benzo[a]pyrene-enhanced mutagenesis by man-made mineral fibres in the lung of alpha-lacl transgenic rats.
Mutat. Res. -Fund. Mol. Mech. Mutag. 595, 167-173 (2006)
In an attempt to examine the interaction of man-made mineral fibres with benzo[a]pyrene (B[a]P), homozygous λ-lacI transgenic F344 rats were intratracheally treated with rock (stone) wool RW1 and glass wool MMVF 10 fibres together with B[a]P. To analyze the induction of gene mutations by fibres and B[a]P in lung, single doses of 1 and 2 mg fibres/animal or multiple doses of 2 mg fibres/animal were administered weekly on 4 consecutive weeks (total dose 8 mg/animal). B[a]P (10 mg/animal) was administered either simultaneously with fibres (for single dose treatment with fibres) or together with the last fiber treatment (for multiple dose treatment with fibres). Animals were scarified 4 weeks after the last treatment. Benzo[a]pyrene administered simultaneously with RW1 fibres exhibited a strong synergistic effect on mutagenicity, the observed mutant frequency (MF) being more than three-fold higher than the net sum of the MF induced after separate administration of both agents. Our data suggest that DNA adducts induced by simultaneous B[a]P and fiber treatment lead to a strong increase in mutatant frequencies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Rock (stone) wool; Glass wool; Benzo[a]pyrene; inflammation; mutations; transgenic rats
ISSN (print) / ISBN 0027-5107
Quellenangaben Band: 595, Seiten: 167-173
Begutachtungsstatus Peer reviewed