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Janzen, T. ; Giussani, A. ; Canzi, C.* ; Gerundini, P.* ; Oeh, U. ; Hoeschen, C.

Investigation of biokinetics of radioiodine with a population kinetics approach.

Radiat. Prot. Dosim. 139, 232-235 (2010)
Open Access Green as soon as Postprint is submitted to ZB.
The dosimetric studies required for planning individually tailored radioiodine therapy of benign thyroid pathologies may be too complex and time-demanding for many ordinary nuclear medicine departments. In this work, a preliminary population kinetics approach was applied to a model structure for iodine biokinetics in order to identify those model features that actually need to be individually investigated, in order to simplify the protocol for data collection in patients. Data from 29 patients undergoing radioiodine therapy for the treatment of the autonomous nodule syndrome were used in the analysis. The greatest inter-individual variations were observed in the parameters describing the transformation of iodide into organic iodine in the thyroid and in the kinetics of the organic form.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Autonomous throid-nodule; Therapy; Dosimetry
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Quellenangaben Volume: 139, Issue: 1-3, Pages: 232-235 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed