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Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes.

Genome Biol. 10:R28 (2009)
Publishers Version DOI PMC
Open Access Gold
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Identifying the biochemical basis of microbial phenotypes is a main objective of comparative genomics. Here we present a novel method using multivariate machine learning techniques for comparing automatically derived metabolic reconstructions of sequenced genomes on a large scale. Applying our method to 266 genomes directly led to testable hypotheses such as the link between the potential of microorganisms to cause periodontal disease and their ability to degrade histidine, a link also supported by clinical studies.
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Publication type Article: Journal article
Document type Review
Keywords isopentenyl diphosphate isomerase; methylerythritol phosphate-pathway; highly toxic clone; escherichia-coli; saccharomyces-cerevisiae; bacillus-subtilis; actinobacillus-actinomycetemcomitans; methanothermobacter-thermautotrophicus; phosphoglycerate mutase; isoprenoid biosynthesis
Reviewing status