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Chromosome aberrations in nuclear power plant workers: The influence of dose accumulation and lymphocyte life-time.

Mutat. Res. -Fund. Mol. Mech. Mutag. 306, 197-202 (1994)
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Chromosome analyses were performed in blood lymphocytes of 22 nuclear power plant workers with a mean accumulated radiation dose of 390 mSv (270-530 mSv). Nineteen workers had received 300 mSv 4-16 years prior to sampling. The frequency of dicentrics and ring chromosomes (1.75 x 10-3) was significantly elevated as compared to a control group (0.58 x 10-3). Based on the initial slope of an in vitro 60Co γ-ray curve, a biological dose estimate of only 110 mSv was derived. This can be interpreted in terms of an 'equivalent-acute' dose at the time of blood sampling which can be derived by weighting annual doses during working periods of 12-30 years for a mean life-time m of lymphocytes. The annual doses were additionally weighted for a uniform distribution during a whole year. Using m = 10 years, a mean 'equivalent-acute' dose of 90 mSv (64-157 mSv) is obtained, which compares more closely to the biologically estimated dose than 20 mSv (7-71 mSv) based on m = 4.3 years.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Chromosome Aberrations ; Dose Accumulation ; Nuclear Power Plant
ISSN (print) / ISBN 0027-5107
e-ISSN 1873-135X
Quellenangaben Volume: 306, Issue: 2, Pages: 197-202 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed