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Restricted expression of HIV1 in human astrocytes: Molecular basis for viral persistence in the CNS.

Res. virol. 145, 147-153 (1994)
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Besides macrophages and microglial cells, cells of astroglial origin are thought to be targets of HIV1 in the brain. HIV1 infection of astroglial cells results in restricted production of the virus. To analyse the molecular basis of this restricted infection phenotype, we established a chronically HIV1-infected low-producer astrocytoma cell line. These cells show only low levels of mRNA encoding structural proteins, due to a cell-determined blockage in the Rev/RRE regulatory axis. The low-producer state could not be overcome by treatment with known stimulators of virus expression such as phorbol ester, (12-O-tetradecanoylphorbol-13-acetate), tumour necrosis factor α or sodium butyrate. This indicates that the molecular mechanisms involved in restricting virus production in astroglial cells differ from those in latently infected T cells and monocytes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Astrocyte ; Cns ; Hiv1 ; Low Producer ; Molecular Mechanism ; Persistence ; Rev Protein
Zeitschrift Research in virology
Quellenangaben Band: 145, Heft: 3-4, Seiten: 147-153 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Paris
Begutachtungsstatus Peer reviewed