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Bridge-building between mathematical theory and molecular biology: The REV2 gene as paradigm.

Mutat. Res. -Fund. Mol. Mech. Mutag. 289, 39-46 (1993)
Open Access Green as soon as Postprint is submitted to ZB.
The DNA damage-repair theory of R.H. Haynes anticipated the possibility of doe-dependent repair processe. The mathematical formalism developed by Haynes and coworkers on the basis of this theory provided tools to probe for the existence of inducible components of mutation or recombination by analysis of dose-response curves. Subsequently, we found that biological and molecular analysis of the Saccharomyces cerevisiae REV2 gene supported the validity of the postulates derived from the mathematical analysis. In this particle, we briefly review the foregoing and summarize ebidence that the REV2 gene product might function in DNA damage-inducible repair and mutation processes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Damage-repair Theory ; Dna Damage-inducible Genes ; Mutation ; Repair
ISSN (print) / ISBN 0027-5107
e-ISSN 1873-135X
Quellenangaben Volume: 289, Issue: 1, Pages: 39-46 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed