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Induction of lipid-protein mismatch by xenobiotics with general membrane targets.

Biochim. Biophys. Acta-Biomembr. 1150, 130-133 (1993)
Open Access Green as soon as Postprint is submitted to ZB.
Many membrane-active xenobiotics, such as organic solvents or general anesthetics, are without specific target sites. A common, but as yet ill-defined physical mechanism of action is usually assumed. Displacement of 'boundary' lipid activators from functional membrane proteins by the induction of lipid/protein mismatch is now established as a candidate common physical mechanism. Multiple binding site kinetics demonstrate that xenobiotics can be strongly inhibitory at realistic membrane concentrations of below 4 mol%. A general equation for inhibition is derived.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Boundary Lipid ; General Anesthetic ; Kinetics ; Membrane Active Compound ; Multiple Binding Site Kinetics ; Xenobiotic
ISSN (print) / ISBN 0005-2736
e-ISSN 1879-2642
Quellenangaben Volume: 1150, Issue: 2, Pages: 130-133 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed