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Influence of amphipathic peptides on the HIV-1 production in persistently infected T lymphoma cells.
FEBS Lett. 309, 235-241 (1992)
The effects of several amphipathic peptides on HIV-1 production in persistently infected cells are described. Melittin, a 26 amino acid α-helical amphipathic peptide, reduces HIV-1 production dose-dependently, whereas other amphipathic peptides do not. Six melittin derivatives which retain the α-helical portion have similar effects as melittin. The reduction of viral infectivity is not due to an effect of melittin on the virus particles but to an intracellular action of the peptide, which is readily taken up into cells, as shown by quantitative ELISA. Western blots of cells from melittin-treated cultures suggest that the processing of the gag/pol precursor is impaired.
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Publication type Article: Journal article
Document type Scientific Article
Keywords α-helix ; Amphipathic Peptide ; Assembly ; Hiv-1 ; Melittin
ISSN (print) / ISBN 0014-5793
Journal FEBS Letters
Quellenangaben Volume: 309, Issue: 3, Pages: 235-241
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)