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Tetrahydro-6-biopterin is associated with tetrahydro-7-biopterin in primary murine mast cells.
FEBS Lett. 307, 147-150 (1992)
Murine bone marrow-derived mast cells proliferate in response to interleukin 3. In addition to 6-biopterin, 7-biopterin was identified in these cells by HPLC analysis of iodine oxidized extracts and by alkaline permanganate oxidation to the 6- and 7-carboxylic acids. 7-Biopterin comprised 31.9 (±7.7)% of the total biopterin. It was absent in cells which were grown with of L-p-chlorophenylalanine, an inhibitor of tryptophan 5-monooxygenase. Both 6- and 7-biopterin were present in the cell as their tetrahydro forms. From these data we conclude that 7-biopterin, in contrast to e.g. brain tissue, regularly occurs as a normal metabolite in primary mast cells and that it is generated during hydroxylation of tryptophan.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 6-biopterin ; 7-biopt Erin ; Mast Cell ; Tetrahydro-6-biopterin ; Tetrahydro-7-biopterin ; Tryptophan 5-mono-oxygenase
ISSN (print) / ISBN 0014-5793
Journal FEBS Letters
Quellenangaben Volume: 307, Issue: 2, Pages: 147-150
Reviewing status Peer reviewed