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Trokovich, R* ; Trokovich, N.* ; Hernesniemi, S.* ; Pirvola, U.* ; Vogt Weisenhorn, D.M. ; Rossant, J.* ; McMahon, A.P.* ; Wurst, W. ; Partanen, J.*

FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals.

EMBO J. 22, 1811-1823 (2003)
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Fibroblast growth factors (FGFs) are signaling molecules of the isthmic organizer, which regulates development of the midbrain and cerebellum. Tissue‐specific inactivation of one of the FGF receptor (FGFR) genes, Fgfr1, in the midbrain and rhombomere 1 of the hindbrain of mouse embryos results in deletion of the inferior colliculi in the posterior midbrain and vermis of the cerebellum. Analyses of both midbrain–hindbrain and midbrain‐specific Fgfr1 mutants suggest that after establishment of the isthmic organizer, FGFR1 is needed for continued response to the isthmic signals, and that it has direct functions on both sides of the organizer. In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell‐adhesion molecules at the midbrain–hindbrain border.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter cerebellum; Cre recombianse; development; FGF; isthmic organizer; midbrain
ISSN (print) / ISBN 0261-4189
e-ISSN 1460-2075
Zeitschrift EMBO Journal, The
Quellenangaben Band: 22, Heft: 8, Seiten: 1811-1823 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Heidelberg, Germany
Begutachtungsstatus Peer reviewed