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Arzneimittelwechselwirkungen in den Verordnungen von Patienten vor und nach dem Herzinfarkt: Resultate, des MONICA Augsburg Herzinfarktregisters.

Soz. Präventivmed. 36, 9-17 (1991)
Open Access Green as soon as Postprint is submitted to ZB.
The prescriptions of 603 patients who had survived acute myocardial infarction (AMI) for at least one year and were registered from 1 Oct 84 to 31 Dec 86 in the Coronary Event Register of the MONICA project Augsburg were analyzed, for the presence of drug-drug interactions with the aid of a computerized drug information system (SMA). Prior to AMI, 59% of patients were treated (average of 2 active substance per patient), 100% were treated on release from hospital (4.5 active substances), and 96% one year after AMI (5.8 active substances). Potential drug-drug interactions were found in 18% of patients before AMI, 65% on discharge from hospital and 66% one year after AMI. While the potential frequency and severity of interactions are minor on average, prescriptions frequently contain several interactions. Calculations show that at least 5-6% of all prescriptions after AMI will produce interactions so that drug safety for this high-risk patient group can be enhanced by a drug information system. Beta-blockers are the substance group most frequently involved in potential interactions in AMI patients.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0303-8408
e-ISSN 1420-911X
Quellenangaben Volume: 36, Issue: 1, Pages: 9-17 Article Number: , Supplement: ,
Publisher Birkhäuser
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)