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The insecticide DDT decreases membrane potential and cell input resistance of cultured human liver cells.

Biochim. Biophys. Acta-Biomembr. 776, 337-339 (1984)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The resting membrane potential, E(m), and the cell input resistance R(i)n(p), of cultured human Chang liver cells were measured using the single electrode 'double-pulse' current clamp technique, following exposure of the cells to the insecticide DDT (20 μM). In control (unexposed) cells, the mean E(m) was -24 mV, and the mean R(inp) was 30 MΩ. Neither parameter was significantly impaired after 1 h of cell exposure to DDT. But after 7 and 48 h, the E(m) was depolarized by 15 and 25 mV, respectively, in parallel with a decrease of the cell input resistance. The strongly time-delayed effect of DDT on Chang liver cell membranes may indicate a mode of interaction different from excitable membranes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0005-2736
e-ISSN 1879-2642
Quellenangaben Band: 776, Heft: 2, Seiten: 337-339 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed