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The insecticide DDT decreases membrane potential and cell input resistance of cultured human liver cells.

Biochim. Biophys. Acta-Biomembr. 776, 337-339 (1984)
Open Access Green as soon as Postprint is submitted to ZB.
The resting membrane potential, E(m), and the cell input resistance R(i)n(p), of cultured human Chang liver cells were measured using the single electrode 'double-pulse' current clamp technique, following exposure of the cells to the insecticide DDT (20 μM). In control (unexposed) cells, the mean E(m) was -24 mV, and the mean R(inp) was 30 MΩ. Neither parameter was significantly impaired after 1 h of cell exposure to DDT. But after 7 and 48 h, the E(m) was depolarized by 15 and 25 mV, respectively, in parallel with a decrease of the cell input resistance. The strongly time-delayed effect of DDT on Chang liver cell membranes may indicate a mode of interaction different from excitable membranes.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0005-2736
e-ISSN 1879-2642
Quellenangaben Volume: 776, Issue: 2, Pages: 337-339 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed